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Publications (since 2012)



 New  Ugachi, Y., Kitade, H., Takahashi, E., Suzuki, S., Hayashi, M., Yamada, T., Cui, W/, and Shimizu, M..* (2023) Size-driven parr-smolt transformation in masu salmon (Oncorhynchus masou). Scientific Reports 13:16643.


Arimoto, M., Izutsu, A., Hara, A., Shimizu, M.* (2023) Evaluation of binding capacity of circulating insulin-like growth factor binding protein-1b in salmonids using a ligand immunofunctional assay. Comp. Biochem. Physiol. A 284:111488.

Izutsu, A., Habara, S., Kaneko, N., Tadokoro, D., Hara, A., Shimizu, M.* (2023) Development of a time-resolved fluoroimmunoassay for salmonid insulin-like growth factor binding protein-2b. Gen. Comp. Endocrinol. 340:114305.


Cui, W., Takahashi, E., Morro, B., Balseiro, P., Albalat, A., Pedrosa, C., Mackenzie, S., Nilsen, T.O., Sveier, H., Ebbesson, L.O., Handeland, S.O., Shimizu, M.* (2022) Changes in circulating insulin-like growth factor-1 and its binding proteins in yearling rainbow trout during spring under natural and manipulated photoperiods and their relationships with gill Na+,K+-ATPase and body size. Comp. Biochem. Physiol. A 268:111205.


Izutsu, A., Tadokoro, D., Habara, S., Ugachi, Y., and Shimizu, M.* (2022) Evaluation of circulating insulin-like growth factor (IGF)-I and IGF-binding proteins as growth indices in rainbow trout (Oncorhynchus mykiss). Gen. Comp. Endocrinol. 320:114008.


Morro, B., Broughton, R., Balseiro, P., Handeland, S.O., Mackenzie, S., Doherty, M.K.. Whitfield, P.D., Shimizu, M., Gorissen, M., Sveier, H., and Albalat, A. (2021) Endoplasmic reticulum stress as a key mechanism in stunted growth of seawater rainbow trout (Oncorhynchus mykiss). BMC Genomics 22:824.

Hayashi, M., Maruoka, S., Oikawa, J., Ugachi, Y., and Shimizu, M.* (2021) Effects of acclimation to diluted seawater on metabolic and growth parameters of underyearling masu salmon (Oncorhynchus masou). Zool. Sci. 38:513-522.


Oikawa, J., Nakamura, S., Kaneko, N., Torao, M., Koshino, Y., and Shimizu, M.* (2021) Effects of fasting and water temperatures during transition from freshwater to seawater on juvenile chum salmon growth and metabolism. Fish. Sci. 87:579–588.


Yamaguchi, G., Habara, S., Suzuki, S., Ugachi, Y., Kawai, H., Nakajima, T., and Shimizu, M.* (2021) Effects of growth hormone and cortisol administration on plasma insulin-like growth factor binding proteins in juveniles of three subspecies of masu salmon (Oncorhynchus masou). Comp. Biochem. Physiol. A 251:110821.


Cleveland, B., Habara, S., Oikawa, J., Radler, L.M., and Shimizu M. (2020) Compensatory response of the somatotropic axis from IGFBP-2b gene editing in rainbow trout (Oncorhynchus mykiss) Genes 11:1488.

Hasegawa, R., Miura, T., Kaneko, N., Kizaki, R., Oishi, G., Tanaka, H., Sato, M., and Shimizu, M.* (2020) Production of recombinant insulin-like growth factor binding protein-1 subtypes specific to salmonids. Gen. Comp. Endocrinol. 299:113606.

Suzuki, S., Takahashi, E., Nilsen T.O., Kaneko, N., Urabe, H., Ugachi, Y., Yamaha, E., and Shimizu, M.* (2020) Physiological changes in off-season smolts induced by photoperiod manipulation in masu salmon (Oncorhynchus masou). Aquaculture 526:735353.

Kalananthan, T., Murashita, K., Rønnestad, I., Ishigaki, M., Takahashi, K., Silva, M.S., Wakabayashi, Y., Lai, F., Shimizu, M., Nilsen, T.O., Martines, E.P., and Gomes, A.S. (2020) Hypothalamic agrp and pomc mRNA responses to gastrointestinal fullness and fasting in Atlantic salmon (Salmo salar, L.). Front. Physiol. 11:61.

Kaneko, N., Nilsen, T.O., Tanaka, H., Hara, A., Shimizu, M.* (2020) Intact rather than total circulating insulin-like growth factor binding protein-1a is a negative indicator of growth in masu salmon. Am. J. Physiol. Regul. Integ. Comp. Physiol. 318:R329-R337.

Morro, B., Balseiro, P., Albalat, A., MacKenzie, S., Pedrosa, C., Nilsen, T.O., Suzuki, S., Shimizu, M., Sveier, H., Corissen, M., Ebbesson, L.O.E., Handeland, S.O. (2020) Effects of temperature and photoperiod on rainbow trout (Oncorhynchus mykiss) smoltification and haematopoiesis. Aquaculture 519: 734711.


Kaneko, N., Journey, M.L., Neville, C.M., Trudel, M., Beckman, B.R., and Shimizu, M.* (2019) Utilization of an endocrine growth index, insuin-like growth factor binding protein (IGFBP)-1b, for postsmolt coho salmon in the Strait of Georgia, British Columbia, Canada. Fish Physiol. Biohem. 45:1867-1878.


Morro, B., Balseiro, P., Albalat, A., Pedrosa, C. Mackenzie, S., Nakamura, S., Shimizu, M., Nilsen, T.O., Sveier, H., Ebbesson, L.O., Handeland, S.O. (2019) Effects of different photoperiod regimes on the smoltification and seawater adaptation of seawater-farmed rainbow trout (Oncorhynchus mykiss): insights from Na+,K+-ATPase activity and transcription of osmoregulation and growth regulation genes. Aquaculture 507:282-292.

Nakamura, S., Kaneko, N., Kurita, D., Miyakoshi, Y., Shimizu, M.* (2019) Fasting in freshwater severely affects growth of juvenile chum salmon when entering cold seawater. Fish. Sci. 85:655-665.

Kaneko, N., Torao, M., Koshino, Y., Fujiwara, M., Miyakoshi, Y., Shimizu, M.* (2019) Evaluation of growth status using endocrine growth indices, insulin-like growth factor (IGF)-I and IGF-binding protein-1b, in out-migrating juvenile chum salmon. Gen. Comp. Endocrinol. 274:50-59.


Cleveland, B.M., Yamaguchi, G., Radler, L.M., Shimizu, M. (2018) Editing the duplicated insulin-like growth factor binding protein-2b gene in rainbow trout (Oncorhynchus mykiss). Sci. Rep. 8:16054.

Inatani, Y., Ineno, T., Sone, S., Matsumoto, N., Uchida, K., and Shimizu, M.* (2018) Assessment of the timing and degree of smolt development in southern populations of masu salmon. J. Fish Biol. 93:490-500.

Balseiro, P., Moe, Ø, Gamlem, I., Shimizu, M., Sveier, H., Nilsen, T.O., Kaneko, N., Ebbesson, L., Pedrosa, C., Tronci, V., Nylund, A., and Handeland, S.O. (2018) Comparison between Atlantic salmon Salmo salar post-smolts reared in open sea cages and in the Preline raceway semi-closed containment aquaculture system. J. Fish Biol. 93:567-579.

Tanaka, H., Oishi, G., Nakano, Y., Mizuta, H., Nagano, Y., Hiramatsu, N., Ando, H., and Shimizu, M.* (2018) Production of recombinant salmon insulin-like growth factor binding protein-1 subtypes. Gen. Comp. Endocrinol. 257:184-191.


Shimizu, M.*, and Dickhoff, W.W. (2017) Circulating insulin-like growth factor binding proteins in fish: their identities and physiological regulation. Gen. Comp. Endocrinol. 252:150-161. (Review article)


Taniyama, N., Kaneko, N., Inatani, Y., Miyakoshi, Y., and Shimizu, M.* (2016) Effects of seawater transfer and fasting on the endocrine and biochemical growth indices in juvenile chum salmon (Oncorhynchus keta). Gen. Comp. Endocrinol. 236:146-156.

Kuwada, T., Tokuhara, T., Shimizu, M., and Yoshizaki, G. (2016) Body size is the primary regulator affecting commencement of smolting in amago salmon Oncorhynchus masou ishikawae. Fish. Sci. 82:59-71.


Hevrøy, E.M., Tipsmark, C.K., Remø, S.C., Hansen, T., Fukuda, M., Torgersen, T., Vikeså, V., Olsvik, P.A., Waagbø, R., and Shimizu, M. (2015) Role of the GH-IGF-1 system in Atlantic salmon and rainbow trout postsmolts at elevated water temperature.  Comp. Biochem. Physiol. A 188:127-138.

Fukuda, M., Kaneko, N., Kawaguchi, K., Hevrøy, E.M., Hara, A., and Shimizu, M.* (2015) Development of a time-resolved fluoroimmunoassay for salmon insulin-like growth factor binding protein-1b. Comp. Biochem. Physiol. A 187:66-73.

Kaneko, N., Taniyama, N., Inatani, Y., Nagano, Y., Fujiwara, M., Torao, M., Miyakoshi, Y., and Shimizu, M.* (2015) Circulating insulin-like growth factor-I in juvenile chum salmon: relationship with growth rate and changes during downstream and coastal migration in northern Hokkaido, Japan. Fish Physiol. Biochem. 41:991-1003.

Kaneko, N., Iijima, A., Shimomura, T., Nakajima, T., Shimura, H., Oomori, H., Urabe, H., Hara, A., and Shimizu, M.* (2015) Profiles of circulating insulin-like growth factor-I during smoltification of masu salmon reared under different conditions. Fish. Sci. 81:643-652.


Nakajima, T., Shimura, H., Yamazaki, M., Fujioka, Y., Ura, K., Hara, A., Shimizu, M.* (2014) Lack of hormonal stimulation prevents the landlocked Biwa salmon (Oncorhynchus masou subsp.) from adapting to seawater. Am. J. Physiol. Regul. Integ. Comp. Physiol. 307:R414-R425.


Kawaguchi, K., Kaneko, N., Fukuda, M., Nakano, Y., Kimura, S., Hara, A., and Shimizu, M.* (2013) Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou). Comp. Biochem. Physiol. A 165:191-198.

Hevrøy, E.M., Hunskår, C., de Gelder, S., Shimizu, M., Waagbø, R., Breck, O., Takle, H., Sussort, S., and Hansen, T. (2013) GH-IGF system regulation of attenuated muscle growth and lipolysis in Atlantic salmon reared at elevated temperatures. J. Comp. Physiol. B 183:243-259.


Shimomura, T., Nakajima, T., Horikoshi, M., Iijima, A., Urabe, H., Mizuno, S., Hiramatsu, N., Hara, A., and Shimizu, M.* (2012) Relationships between gill Na+,K+-ATPase activity and endocrine and local insulin-like growth factor-I levels during smoltification of masu salmon (Oncorhynchus masou). Gen. Comp. Endocrinol. 178:427-435.

Metzger, D.C., Luckenbach, J.A., Shimizu, M., and Beckman, B.R. (2012) Normalizing for biology: accounting for technical and biological variation in levels of reference gene and insulin-like growth factor 1 (igf1) transcripts in fish livers. Comp. Biochem. Physiol. A 163:7-14.

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